SAEDNEWS: Researchers Discover Extremely Rare New Blood Group ‘MAL’ After 50 Years of Study
According to SaedNews Science & Technology Service, researchers have discovered a new and extremely rare blood group called MAL after 50 years of studying a blood sample that lacked a common surface molecule. This breakthrough, achieved through the identification of a genetic mutation, may help doctors save the lives of patients with similar blood conditions in the future.
As reported by Khabar Online, a medical mystery that had puzzled scientists since 1972 has finally been solved. British researchers, after decades of studying the blood of a pregnant woman who lacked an antigen present in over 99.9% of the population, successfully characterized a completely new human blood group. Named MAL, this discovery opens new horizons in transfusion science and the diagnosis of rare blood disorders.
Solving a 50-Year-Old Mystery
The story began with a peculiar blood sample, mysteriously missing the AnWj antigen. Scientists discovered that this antigen resides on a protein called MAL.
Genetic Origin: Final research published in 2024 revealed that this rare blood group is caused by a mutation in the MAL gene.
Significance of the Discovery: Dr. Louise Tilly, a hematology specialist, described this achievement as “the culmination of a long-standing effort,” allowing physicians to provide better care for patients with this rare condition.
Why This Discovery Matters
Understanding all blood groups is critical because antigen mismatches during transfusions can trigger severe and even fatal reactions.
Disease Diagnosis: With the genetic marker of this new blood group now identified, doctors can test whether an individual’s MAL-negative blood is inherited or due to antigen suppression by an underlying condition, potentially signaling other medical concerns.
Small Protein, Big Role: Despite its small size, the MAL protein plays a vital role in maintaining the stability of the cell membrane.
