SAEDNEWS: According to recent reports, some of the recent issues can be attributed to the failure of batteries at operator sites. The statement mentioned that over the past month, the Ministry of Communications and Information Technology and the Regulatory Authority have been working to resolve these issues.
According to SaedNews, while bones can regenerate, teeth are not as fortunate. This has led millions worldwide to suffer from tooth loss due to various reasons, including neglect or fractures. Many seek a solution for tooth regrowth, and it seems this possibility will soon be realized.
If the trials are successful, researchers hope that the tooth regrowth injection will be available for all types of tooth loss by around 2030.
The trial details reveal that Japanese researchers are transitioning animal trials of a promising tooth regrowth drug to human trials. The first patients received this drug via intravenous injection in September this year. Katsuo Takahashi, head of dentistry at the Medical Research Institute at Kitano Hospital in Osaka, said, "We want to help those who suffer from tooth loss."
In 2007, researchers discovered that mice with the USAG-1 gene had extra teeth. However, the protein of this gene is involved in the growth of many body parts, so removing it to stimulate tooth growth was not an option. Instead, researchers began testing various monoclonal antibodies (lab-made proteins designed to bind to specific molecules) on mice born with fewer teeth than usual. The USAG-1 gene antibody could stimulate tooth growth, and scientists have since worked on creating a "neutralizing antibody drug" that can block USAG-1. In 2021, they reported discovering such an antibody and noted that it also promotes tooth growth in ferrets, which have dental patterns similar to humans, according to Takahashi.
Researchers are preparing to test the safety of their monoclonal antibody, TRG035, in individuals with congenital tooth agenesis, the same condition observed in the 2021 mouse study. If proven safe, trials will be conducted to test its effectiveness. Tooth agenesis is a developmental anomaly resulting in the absence of one or more teeth. It is one of the most common dental anomalies, ranging from the absence of a single tooth to complete anodontia, where all teeth are missing.
